pain numbness weakness conjunctivitis

The mid-70s, Children in Lyme, CT

arthritis

 

In the mid-70s, Children in Lyme, CT

arthritis

rash

 

 

The mid-70s, Children in Lyme, CT

arthritis

rash

conjunctivitis

 

 

The mid-70s, Children in Lyme, CT

arthritis

rash

conjunctivitis

fatigue/fever headache stiff neck

 

 

The mid-70s, Children in Lyme, CT

arthritis

rash

pain numbness weakness

conjunctivitis

fatigue/fever headache stiff neck

 

 

Mid-70s, Children in Lyme, CT

arthritis

facial paralysis

rash

pain numbness weakness

conjunctivitis

fatigue/fever headache stiff neck

 

 

Mid-70s, Children in Lyme, CT

arthritis

facial paralysis

rash

pain numbness weakness

conjunctivitis

fatigue/fever headache stiff neck

cardiac and/or neurological symptoms

 

 

What caused this illness?

Early 1980’s: the gram-negative bacterium Borrelia burgdorferi

 

 

Identification of Borrelia as causative agent of Lyme disease

• Isolate single colonies of Borrelia from ticks • Grow up colonies, feed to ticks • Let ticks bite rabbits • See rash • Isolate Borrelia from people with Lyme

disease

 

 

How were the children exposed to this bacterium?

Dime

Photos by John VanDyk, Iowa State Univ.

 

 

How were the children exposed to this bacterium?

Dime

Photos by John VanDyk, Iowa State Univ.

…via tick saliva (yuck!)

 

 

Tick after feeding….

Must feed for at least 24 hours to pass on Borrelia burgdorferi bacteria to its host

 

 

How did ticks get infected with Borrelia bergdorferi?

?

 

 

How did ticks get infected with Borrelia bergdorferi?

 

 

How did ticks get infected with Borrelia bergdorferi?

reservoirs

 

 

Life cycle of Borrelia burgdorferi in the tick (Ixodes)

 

 

What we’ve discussed so far…

 

 

Lyme disease is NOT a new disease

• 1883 Lyme-related symptoms reported in Germany

• 1909 Linked Lyme-related symptoms with tick bites in Sweden

• ~1950 Treat symptoms with antibiotics in Europe

• 1970 First tick-related rash reported in USA

 

 

2002 Lyme Disease Cases by State as Reported to CDC n=23,763

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